Evaluation of antimicrobial resistance among the clinically isolated S. aureus and E. coli from a hospital in Karachi, Pakistan

Abstract

The surfacing and extend of antibiotic resistance in different organisms (parasites, fungi, bacteria, and virus) is among the mainly important health troubles of the world today. The battle to antimicrobial drugs has increased at society and mostly at hospital settings. Pan-resistant strains (organisms resistant to all antibiotics), multidrug-resistant (MDR), and extensively drug resistant (XDR) is antibiotic treatment decline and it has amplified morbidity, and mortality, along with important effects on the price of remedial treatment of bacterial infectious diseases. In this study antibiotic resistance of different groups of commonly used antibiotics has been studied for clinically isolated of S.aureus and E.coli grown by Blood, Urine, and Pus samples. All samples have been collected at Memon Medical Institute (MMI) Hospital, Karachi. Sixty-four clinical specimens were tested for their antibiogram pattern with broadly used antibiotics for the treatment of bacterial infections. Results indicated a range of 0 to 100% of antibiotic resistance showing a failure in antibiotic activity against E. coli and S.aureus. Piperacillin + Tazobactam (Ta), Cefoperazone + Sulbactum (Sul), Ciprofloxicin/Ofloxocin, Co-trimoxazole, and Aztreonam (Azactum) were 100% resistance by E.coli isolated from pus samples whereas, S.aureus showed resistance against Erythromycin 60% from pus, Ciprofloxicin/Ofloxocin57.14% from pus and urine, and Meropenem 57.14% from pus.